Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Coronavirus / growth & development
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Coronavirus / pathogenicity*
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Coronavirus Infections / immunology
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Coronavirus Infections / metabolism
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Coronavirus Infections / virology*
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Humans
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Immunity, Innate / immunology*
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Interferon Type I / antagonists & inhibitors*
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Middle East
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Molecular Sequence Data
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RNA, Double-Stranded / metabolism
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Sequence Homology, Amino Acid
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Severe Acute Respiratory Syndrome / immunology
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Severe Acute Respiratory Syndrome / metabolism
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Severe Acute Respiratory Syndrome / virology*
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Viral Regulatory and Accessory Proteins / metabolism*
Substances
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Interferon Type I
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RNA, Double-Stranded
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Viral Regulatory and Accessory Proteins