Coordination of TGF-β signaling by ubiquitylation

Mol Cell. 2013 Sep 12;51(5):555-6. doi: 10.1016/j.molcel.2013.08.034.

Abstract

In this issue, Zhang et al. (2013) demonstrate that the ubiquitin ligase TRAF4 associates with the TGF-β receptors, rescuing them from degradation and ubiquitylating TAK1 to activate non-Smad signaling, which together promote metastasis of breast cancer cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology*
  • Female
  • Humans
  • Receptors, Transforming Growth Factor beta / metabolism*
  • TNF Receptor-Associated Factor 4 / genetics*
  • TNF Receptor-Associated Factor 4 / metabolism*

Substances

  • Receptors, Transforming Growth Factor beta
  • TNF Receptor-Associated Factor 4
  • TRAF4 protein, human