Hypercoagulability in a newborn with concomitant homozygous factor V Leiden and severe homozygous protein C deficiency type 1

Blood Coagul Fibrinolysis. 2013 Oct;24(7):777-9. doi: 10.1097/MBC.0b013e328364194b.

Abstract

This is a case report of a female newborn presented with skin necrotic lesions 1 week after delivery. Laboratory investigations revealed severe homozygous protein C deficiency associated with homozygous factor V Leiden, although her pregnancy and perinatal periods were otherwise uneventful, with negative family history of thrombotic or bleeding disorders. Patient stabilization was established by supportive measures and long-term administration of fresh frozen plasma and warfarin.

Publication types

  • Case Reports

MeSH terms

  • Blood Coagulation Disorders, Inherited / blood*
  • Factor V / metabolism*
  • Female
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Protein C Deficiency / blood*
  • Risk Factors
  • Thrombophilia / blood*

Substances

  • factor V Leiden
  • Factor V