1 Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy, Centre for Statistical Methodology, London School of Hygiene and Tropical Medicine, London, UK, Departments of Medical Statistics and Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK and Centre for Public Health Research, Massey University, Wellington, New Zealand.