Dual-sugar imaging using isonitrile and azido-based click chemistries

Org Biomol Chem. 2013 Nov 14;11(42):7297-300. doi: 10.1039/c3ob41805g.

Abstract

We report the first account of metabolically labelling N-acetylglucosamine, in conjunction with either N-acetylgalactosamine or N-acetylmannosamine using a combination of isonitrile- and azide-based chemistries. With the appropriately labelled fluorescent probe molecules, that react with either the azido or isonitrile groups, the method enabled co-visualisation of cancer cell glycoproteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylglucosamine / metabolism*
  • Azides / chemistry*
  • Cell Line
  • Click Chemistry*
  • Fluorescent Dyes / chemistry*
  • Molecular Imaging / methods*
  • Nitriles / chemistry*
  • Staining and Labeling

Substances

  • Azides
  • Fluorescent Dyes
  • Nitriles
  • Acetylglucosamine