Abstract
Molecular techniques were used to characterize genetic features of Staphylococcus aureus in 66 fatal cases of pneumonia caused by S. aureus and influenza A or B viruses. Nucleic acids were extracted from formalin-fixed, paraffin-embedded tissues. The majority of cases revealed genetic markers for Panton-Valentine leukocidin, mecA, and spa type t008.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Bacterial Proteins / genetics
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Bacterial Toxins / genetics
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Child
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Child, Preschool
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Coinfection / microbiology*
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Coinfection / virology*
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Exotoxins / genetics
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Female
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Genotype
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Humans
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Infant
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Influenza, Human / complications*
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Influenza, Human / virology
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Leukocidins / genetics
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Male
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Middle Aged
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Orthomyxoviridae / genetics
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Orthomyxoviridae / isolation & purification*
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Penicillin-Binding Proteins
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Pneumonia, Staphylococcal / complications*
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Pneumonia, Staphylococcal / microbiology
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Staphylococcal Protein A / genetics
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Staphylococcus aureus / genetics
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Staphylococcus aureus / isolation & purification*
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Young Adult
Substances
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Bacterial Proteins
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Bacterial Toxins
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Exotoxins
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Leukocidins
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Panton-Valentine leukocidin
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Penicillin-Binding Proteins
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Staphylococcal Protein A
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mecA protein, Staphylococcus aureus