Complete remission of brain metastases of ovarian cancer following high-dose carboplatin: a case report and pharmacokinetic study

Cancer Chemother Pharmacol. 1990;25(5):382-3. doi: 10.1007/BF00686244.

Abstract

Brain metastases developed in a 40-year-old woman with relapsed ovarian cancer 2 years after cisplatin-based combination chemotherapy. After a single dose of 800 mg/m2 carboplatin, complete remission of the brain metastases occurred. A pharmacokinetic study during the second course revealed low levels of carboplatin in the cerebrospinal fluid.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / secondary
  • Carboplatin
  • Cystadenocarcinoma / pathology*
  • Female
  • Humans
  • Organoplatinum Compounds / administration & dosage*
  • Organoplatinum Compounds / adverse effects
  • Organoplatinum Compounds / pharmacokinetics
  • Ovarian Neoplasms / pathology*

Substances

  • Organoplatinum Compounds
  • Carboplatin