Abstract
A metal-free oxidative spirocyclization of hydroxymethylacrylamide with 1,3-dicarbonyl compounds is described. The reaction proceeds through tandem dual C-H functionalization and intramolecular dehydration, in which two new C-C bonds and one C-O bond were formed. This method affords a novel and straightforward access to various spirooxindoles under mild conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylamides / chemistry*
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Cyclization
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Indoles / chemical synthesis*
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Indoles / chemistry
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Ketones / chemistry*
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Models, Molecular
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Molecular Structure
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Oxidation-Reduction
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Oxindoles
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
Substances
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Acrylamides
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Indoles
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Ketones
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Oxindoles
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Spiro Compounds
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2-oxindole