Mutational analysis of breast cancer: guiding personalized treatments

Breast. 2013 Aug:22 Suppl 2:S19-21. doi: 10.1016/j.breast.2013.07.003.

Abstract

The application of high throughput techniques to profile DNA, RNA and protein in breast cancer samples from hundreds of patients has profoundly increased our knowledge of the disease. However there remain many knowledge gaps that will require a long process of extended clinical correlation studies, deeper integrated 'omic analysis and functional annotation to address. This article reviews conclusions from recent breast cancer 'omics profiling' papers and considers pathways forward for extracting medically valuable information from large dimension data sets.

Keywords: Breast cancer; Genomics; Somatic mutation; Therapeutic road map; Whole genome sequencing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / mortality
  • Breast Neoplasms / therapy*
  • Combined Modality Therapy
  • DNA Mutational Analysis
  • Female
  • Gene Expression Profiling / methods*
  • Genes, erbB-2 / genetics
  • Genetic Predisposition to Disease*
  • Genomics
  • Humans
  • Mastectomy / methods
  • Mastectomy / mortality
  • Middle Aged
  • Precision Medicine / methods*
  • Prognosis
  • Risk Assessment
  • Sequence Analysis, DNA
  • Survival Analysis
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Hormonal