Cerebral organoids in a dish: progress and prospects

Marina Bershteyn; Arnold R Kriegstein

doi:10.1016/j.cell.2013.09.010

Cerebral organoids in a dish: progress and prospects

Cell. 2013 Sep 26;155(1):19-20. doi: 10.1016/j.cell.2013.09.010.

Authors

Marina Bershteyn¹, Arnold R Kriegstein

Affiliation

¹ Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, 35 Medical Center Way, San Francisco, CA 94143, USA; University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.

Publication types

Comment

MeSH terms

Animals
Brain / growth & development*
Brain / pathology*
Humans
Microcephaly / pathology*
Models, Biological*
Organoids / cytology*
Organoids / growth & development*
Tissue Culture Techniques / methods*

Grants and funding

R01 NS072630/NS/NINDS NIH HHS/United States