Novel intergenotype human norovirus recombinant GII.16/GII.3 in Bangladesh

Infect Genet Evol. 2013 Dec:20:325-9. doi: 10.1016/j.meegid.2013.09.021. Epub 2013 Sep 27.

Abstract

Noroviruses (NoVs) are one of the major etiological agents of acute gastroenteritis in all age groups. In this study, we identified an intergenotype NoV recombinant strain in the fecal specimens of two male infants with acute diarrhea in Bangladesh. Phylogenetic analysis showed that the identified strains were recombinant NoV strains with a GII.3 capsid and a GII.16 polymerase gene. The recombination breakpoint was located in the ORF1/ORF2 overlap region. To the best of our knowledge this is the first report of a NoV recombinant GII.16/GII.3 strain worldwide.

Keywords: Bangladesh; Diarrhea; GII.16; GII.3; Norovirus; Recombinant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bangladesh
  • Base Sequence
  • Caliciviridae Infections / genetics*
  • Caliciviridae Infections / virology
  • Capsid Proteins / genetics*
  • Diarrhea / virology
  • Feces / virology
  • Gastroenteritis / genetics*
  • Gastroenteritis / virology
  • Genetic Variation
  • Humans
  • Infant
  • Male
  • Molecular Sequence Data
  • Norovirus / classification
  • Norovirus / genetics*
  • Norovirus / isolation & purification
  • Open Reading Frames / genetics
  • Phylogeny
  • RNA, Viral / genetics
  • RNA-Dependent RNA Polymerase / genetics*
  • Recombination, Genetic
  • Sequence Analysis, RNA

Substances

  • Capsid Proteins
  • RNA, Viral
  • RNA-Dependent RNA Polymerase

Associated data

  • GENBANK/JX683114
  • GENBANK/JX683115