Aim: This study was conducted to optimize the "heat-conduct effect" to increase the efficacy of radiofrequency ablation (RFA) in the treatment of liver tumors.
Methods: To simulate the "heat-conduct effect" caused by RFA, isolated pig livers were heated by an inserted metal tube through which water with different incoming temperatures was passed. The tissue temperature was measured within 5- and 10-mm radiuses. Further, changes in color and morphology of the tissue were recorded.
Results: Using an incoming temperature of 70 °C, the effective ablation radius of 5 mm was achieved within 10 min. To expand the effective radius to 10 mm, the tube temperature needed to be maintained at above 80 °C for 40 min; alternatively, the tube temperature above 90 °C and heating time of 25 min were also sufficient.
Conclusion: To achieve the complete ablation in isolated liver within the 10 mm radius by "heat-conduct effect", the temperature of the heating center should be maintained above 80 - 90 °C with the exposure time of 25-40 min.