Lately, neuromodulation of the brain is considered one of the promising applications of ultrasound technology in which low-intensity focused ultrasound (LIFU) is used noninvasively to excite or inhibit neuronal activity. In LIFU, one of critical barriers in the propagation of ultrasound wave is the skull, which is known to be highly anisotropic mechanically: this affects the ultrasound focusing, thereby neuromodulation effects. This study aims to investigate the influence of the anisotropic properties of the skull on the LIFU via finite element head models incorporating the anisotropic properties of the skull. We have examined the pressure and stress distributions within the head in LIFU. Our results show that though most of the pressure that reaches to the brain is due to the longitudinal wave propagation through the skull, the normal stress in the transverse direction of the wave propagation has the main role to control the pressure profile inside the brain more than the shear stress. The results also show that the anisotropic properties of skull contribute in broadening the focal zone in comparison to that of the isotropic skull.