Abstract
The relationship between mold and asthma has been recognized for decades, but the molecular triggers of asthma generated by molds have not been fully elucidated. A glycolipid generated by Aspergillus species has recently been identified that triggers airway hyperreactivity via natural killer T cell activation. The synthesis of this glycolipid and structural variants designed to allow identification of the features of this glycolipid required for recognition by natural killer T cells is described.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
Aspergillus / chemistry*
-
Dendritic Cells / drug effects
-
Dose-Response Relationship, Drug
-
Enzyme-Linked Immunosorbent Assay
-
Interferon-gamma / analysis
-
Interleukin-4 / analysis
-
Mice
-
Molecular Conformation
-
Natural Killer T-Cells / drug effects*
-
Sphingolipids / chemical synthesis*
-
Sphingolipids / chemistry
-
Sphingolipids / pharmacology*
-
Structure-Activity Relationship
Substances
-
1-O-beta-D-glucopyranosyl-(2S,2'R,3R,3'E,4E,8E)-N-(2'-hydroxy-3'-hexadecenoyl)-9-methyl-4,8-icosadien-1,3-diol
-
Sphingolipids
-
Interleukin-4
-
Interferon-gamma