Hypoxia signaling--license to metastasize

Cancer Discov. 2013 Oct;3(10):1103-4. doi: 10.1158/2159-8290.CD-13-0481.

Abstract

Hypoxia-inducible factors (HIF) have long been linked to malignant tumor phenotypes in various cancer types, and several downstream mediators of HIF action are deregulated in metastatic carcinomas. A new study links hypoxia-induced collagen remodeling to sarcoma progression, providing evidence for unifying mechanisms of carcinoma and sarcoma metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cell Hypoxia*
  • Collagen / metabolism*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • Minoxidil / pharmacology*
  • Neoplasm Metastasis*
  • Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase / antagonists & inhibitors*
  • Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase / metabolism*
  • Sarcoma / pathology*
  • Sarcoma / secondary*

Substances

  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Minoxidil
  • Collagen
  • Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase