Plasmid copy number and disease severity in naturally occurring ocular Chlamydia trachomatis infection

J Clin Microbiol. 2014 Jan;52(1):324-7. doi: 10.1128/JCM.02618-13. Epub 2013 Nov 6.

Abstract

The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]) and there were no associations with C. trachomatis load or disease severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Load
  • Child
  • Child, Preschool
  • Chlamydia trachomatis / genetics*
  • Chlamydia trachomatis / pathogenicity
  • Female
  • Gene Dosage*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Plasmids*
  • Severity of Illness Index
  • Trachoma / microbiology*
  • Trachoma / pathology*
  • Virulence
  • Young Adult