The psychosocial problems associated with breast cancer have commanded more and more attention. Historical developments in medicine and society have altered the context in which breast cancer is diagnosed and treated. There are many new issues for researchers interested in quality-of-life issues surrounding breast cancer, and findings from past research must be evaluated carefully. Accordingly, this article reviews: (a) historical developments affecting the context of breast cancer research, (b) aspects of breast cancer and its treatments that challenge well-being, (c) the literature considering breast cancer's psychosocial sequelae, and (d) variables that may influence the intensity of its impact. In addition, we offer some directions for future research.