Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers

Anne Irene Hagen; Lovise Mæhle; Nina Vedå; Hildegunn Høberg Vetti; Astrid Stormorken; Trond Ludvigsen; Bente Guntvedt; Anne Elisabeth Isern; Ellen Schlichting; Geir Kleppe; Anna Bofin; Hans Petter Gullestad; Pål Møller

doi:10.1016/j.breast.2013.10.002

Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers

Breast. 2014 Feb;23(1):38-43. doi: 10.1016/j.breast.2013.10.002. Epub 2013 Nov 5.

Authors

Affiliations

¹ Department of Breast and Endocrine Surgery, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: anne.i.hagen@ntnu.no.
² Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
³ Western Norway Familial Cancer Center, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
⁴ Department of Pathology and Medical Genetics, Trondheim University Hospital, Trondheim, Norway.
⁵ Department of Medical Genetics, University Hospital of North Norway, Tromsø, Norway.
⁶ Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Teres Stokkan, Teres Medical Group, Trondheim, Norway.
⁷ Department of Breast and Endocrine Surgery, Oslo University Hospital, Oslo, Norway.
⁸ Department of Breast and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway.
⁹ Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
¹⁰ Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.

PMID: 24210736
DOI: 10.1016/j.breast.2013.10.002

Abstract

The aim of this study was to evaluate the outcome of risk-reducing mastectomy in BRCA1/2 mutation carriers with and without breast cancer. Uptake, methods of operation and reconstruction, complications, patient satisfaction and histopathological findings were registered at all five departments of genetics in Norway. Data from 267 affected and unaffected BRCA1/2 mutation carriers were analyzed, including a study-specific questionnaire returned by 178 mutation carriers. There was a steady increase in the uptake of risk-reducing mastectomies during the study period. Complications were observed in 106/266 (39.7%) women. Patient satisfaction was high. The majority of women expressed great relief after risk-reducing mastectomy and would have chosen the same option again.

Keywords: BRCA1; BRCA2; DIEP; Reconstruction; Risk-reducing mastectomy; SGAP; TRAM; deep inferior epigastric perforator flap; superior gluteal artery perforator flap; transverse rectus abdominal myocutaneous flap.

MeSH terms

Adult
Breast Neoplasms / genetics
Breast Neoplasms / prevention & control*
Breast Neoplasms / surgery
Cohort Studies
Female
Genes, BRCA1*
Genes, BRCA2*
Heterozygote
Humans
Mammaplasty* / psychology
Mastectomy* / psychology
Middle Aged
Norway
Patient Satisfaction*
Retrospective Studies