HUS and TTP in Children

Pediatr Clin North Am. 2013 Dec;60(6):1513-26. doi: 10.1016/j.pcl.2013.08.007.

Abstract

This review describes the epidemiology, pathophysiology, presentation, clinical causes, treatment, and long-term prognosis of pediatric patients who present with thrombotic microangiopathy. The focus is on hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, the most common phenotypes of thrombotic microangiopathy.

Keywords: Alternative pathway of complement (APC); Hemolytic uremic syndrome (HUS); Shiga toxin (Stx); Thrombotic microangiopathy (TMA); Thrombotic thrombocytopenic purpura (TTP).

Publication types

  • Review

MeSH terms

  • Child
  • Hemolytic-Uremic Syndrome / etiology*
  • Hemolytic-Uremic Syndrome / physiopathology
  • Hemolytic-Uremic Syndrome / therapy
  • Humans
  • Purpura, Thrombotic Thrombocytopenic / etiology*
  • Purpura, Thrombotic Thrombocytopenic / physiopathology
  • Purpura, Thrombotic Thrombocytopenic / therapy