Abstract
A randomized controlled trial has started in Japan to evaluate the efficacy of extensive intraoperative peritoneal lavage in the treatment of resectable advanced gastric cancer. Patients with T3 or deeper carcinoma of the stomach are intraoperatively randomized to either extensive intraoperative peritoneal lavage + arm or extensive intraoperative peritoneal lavage- arm. A total of 300 patients will be accrued from 20 institutions. The primary endpoint is disease-free survival, and secondary end-points are overall survival, peritoneal recurrence-free survival and incidence of adverse events.
Keywords:
Phase III; clinical trial; gastrectomy; gastric cancer; peritoneal lavage.
Publication types
-
Clinical Trial, Phase III
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Carcinoma / mortality
-
Carcinoma / pathology
-
Carcinoma / surgery
-
Carcinoma / therapy*
-
Chemotherapy, Cancer, Regional Perfusion
-
Disease-Free Survival
-
Female
-
Gastrectomy*
-
Humans
-
Japan / epidemiology
-
Male
-
Middle Aged
-
Neoplasm Recurrence, Local / epidemiology
-
Neoplasm Recurrence, Local / prevention & control
-
Peritoneal Lavage*
-
Peritoneal Neoplasms / epidemiology
-
Peritoneal Neoplasms / mortality
-
Peritoneal Neoplasms / secondary
-
Peritoneal Neoplasms / therapy*
-
Prognosis
-
Stomach Neoplasms / mortality
-
Stomach Neoplasms / pathology
-
Stomach Neoplasms / surgery
-
Stomach Neoplasms / therapy*
-
Treatment Outcome