Pathogenicity of clinical Acinetobacter baumannii isolates in a Galleria mellonella host model according to bla(OXA-40) gene and epidemiological outbreak status

Antimicrob Agents Chemother. 2014;58(2):1240-2. doi: 10.1128/AAC.02201-13. Epub 2013 Dec 2.

Abstract

Clinical studies have suggested that blaOXA-40-positive Acinetobacter baumannii isolates are associated with poor patient outcomes; however, reasons for unfavorable outcomes are difficult to discern in clinical studies. The objective of this study was to assess the virulence of carbapenem-resistant A. baumannii according to blaOXA-40 and epidemiological outbreak status in a Galleria mellonella model. Eight isolates of A. baumannii were studied. Nonoutbreak isolates and blaOXA-40-negative isolates more rapidly killed infected G. mellonella (P < 0.01).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / epidemiology*
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / genetics
  • Acinetobacter baumannii / isolation & purification
  • Acinetobacter baumannii / pathogenicity*
  • Animals
  • Chicago / epidemiology
  • Disease Outbreaks*
  • Gene Expression
  • Humans
  • Larva / microbiology*
  • Models, Biological
  • Moths / microbiology*
  • Plasmids
  • Virulence
  • beta-Lactamases / classification
  • beta-Lactamases / genetics*

Substances

  • beta-Lactamases
  • beta-lactamase OXA-40, Acinetobacter baumannii