A novel indigoid anti-tuberculosis agent

Bioorg Med Chem Lett. 2014 Jan 1;24(1):268-70. doi: 10.1016/j.bmcl.2013.11.024. Epub 2013 Nov 21.

Abstract

The structure of a novel indigoid component was characterized by X-ray crystallography. This compound exhibited excellent anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv in whole cell culture showing a submicromolar minimum inhibitory concentration (MIC). A synthesis of this molecule was designed and carried out to produce sufficient material for further testing. The in vitro profile, structure, and first synthesis of this indigoid component is reported.

Keywords: Anti-tuberculosis; Indigoid; X-ray.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antitubercular Agents / chemical synthesis
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology*
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects*
  • Structure-Activity Relationship

Substances

  • Antitubercular Agents