Neurologic aspects of lymphoma and leukemias

Handb Clin Neurol. 2014:120:1027-43. doi: 10.1016/B978-0-7020-4087-0.00069-3.

Abstract

The lymphomas and leukemias are a heterogenous group of hematologic malignancies with protean manifestations. Neurologic sequelae of the diseases have been recognized since the time the conditions were first described in the mid-1800s. Although our understanding of the various presentations of these blood disorders evolved along with our knowledge of malignancies, accurate diagnosis can still be difficult. It is critical for neurologists to have a high index of clinical suspicion to appropriately recognize their heralding features. This review's focus is the relevant clinical neurologic features and diagnostic studies that identify leukemias and lymphomas affecting the nervous system.

Keywords: ALL (acute lymphoblastic leukemia); AML (acute myeloid leukemia); APL (acute promyelocytic leukemia); CLL (chronic lymphocytic leukemia); CML (chronic myelogenous leukemia); Hodgkin lymphoma; Leukemia; lymphoma; non-Hodgkin lymphoma.

Publication types

  • Review

MeSH terms

  • Humans
  • Leukemia / complications*
  • Lymphoma / complications*
  • Nervous System Diseases / etiology*