A developmental program drives aggressive embryonal brain tumors

Nat Genet. 2014 Jan;46(1):2-3. doi: 10.1038/ng.2857.

Abstract

Embryonal tumors with multilayered rosettes (ETMRs) are primitive neuroectodermal tumors arising in infants. A new study shows that these tumors are universally driven by fusion of the promoter of a gene with brain-specific expression, TTYH1, to C19MC, the largest human microRNA cluster, activating a fetal neural development program.

Publication types

  • News
  • Comment

MeSH terms

  • Brain Neoplasms / genetics*
  • Chromosomes, Human, Pair 19*
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA Methyltransferase 3B
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • MicroRNAs / genetics*
  • Neoplasms, Germ Cell and Embryonal / genetics*

Substances

  • Membrane Proteins
  • MicroRNAs
  • TTYH1 protein, human
  • DNA (Cytosine-5-)-Methyltransferases