Click chemistry plays a dual role in biodegradable polymer design

Adv Mater. 2014 Mar 26;26(12):1906-11. doi: 10.1002/adma.201305162. Epub 2013 Dec 23.

Abstract

Click chemistry plays a dual role in the design of new citrate-based biodegradable elastomers (CABEs) with greatly improved mechanical strength and easily clickable surfaces for biofunctionalization. This novel chemistry modification strategy is applicable to a number of different types of polymers for improved mechanical properties and biofunctionality.

Keywords: biofunctionalization; citric acid; click chemistry; elastomers; polymers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biocompatible Materials / chemistry*
  • Cell Proliferation
  • Cell Survival / drug effects
  • Cells, Cultured
  • Citrates / chemistry
  • Click Chemistry*
  • Elastic Modulus
  • Elastomers / chemistry*
  • Epithelial Cells / drug effects
  • Epithelial Cells / physiology
  • Epithelial Cells / ultrastructure
  • Humans
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Polymers / chemistry
  • Tensile Strength
  • Tissue Scaffolds / chemistry*
  • Umbilical Veins / drug effects
  • Umbilical Veins / physiology
  • Umbilical Veins / ultrastructure

Substances

  • Biocompatible Materials
  • Citrates
  • Elastomers
  • Polymers
  • poly(1,8-octanediol citrate)