The function of BAFF on T helper cells in autoimmunity

Maogen Chen; Xiaohong Lin; Ya Liu; Qiang Li; Yiling Deng; Zhongmin Liu; David Brand; Zhiyong Guo; Xiaoshun He; Bernhard Ryffel; Song Guo Zheng

doi:10.1016/j.cytogfr.2013.12.011

The function of BAFF on T helper cells in autoimmunity

Cytokine Growth Factor Rev. 2014 Jun;25(3):301-5. doi: 10.1016/j.cytogfr.2013.12.011. Epub 2013 Dec 24.

Authors

Maogen Chen¹, Xiaohong Lin², Ya Liu³, Qiang Li⁴, Yiling Deng³, Zhongmin Liu⁵, David Brand⁶, Zhiyong Guo⁷, Xiaoshun He⁸, Bernhard Ryffel⁹, Song Guo Zheng¹⁰

Affiliations

¹ Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China; Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
² Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA; Department of Thyroid and Breast Surgery, Huangpu Branch of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510700, PR China.
³ Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
⁴ Division of Rheumatology at Penn State University Hershey College of Medicine, Hershey, PA 17033, USA.
⁵ Institute of Immunology and Transplantation, Shanghai East Hospital at Tongji University, Shanghai, PR China.
⁶ Research Service, Veterans Affairs Medical Center, Memphis, USA.
⁷ Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China.
⁸ Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China. Electronic address: gdtrc@163.com.
⁹ University of Orléans and Molecular Immunology and Embryology, CNRS UMR6218, Orleans, France; IIDMM, University of Cape Town, South Africa.
¹⁰ Division of Rheumatology at Penn State University Hershey College of Medicine, Hershey, PA 17033, USA; Institute of Immunology and Transplantation, Shanghai East Hospital at Tongji University, Shanghai, PR China. Electronic address: szheng1@hmc.psu.edu.

Abstract

B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.

Keywords: BAFF; T helper cells; Tfh cells; Th17; Treg cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autoantibodies / immunology
B-Cell Activating Factor / immunology*
B-Lymphocytes / immunology
B-Lymphocytes / pathology
Cell Differentiation / immunology*
Cell Proliferation*
Cell Survival / immunology
Humans
Hypergammaglobulinemia / immunology
Hypergammaglobulinemia / pathology
Immune Complex Diseases / immunology
Immune Complex Diseases / pathology
Immunoglobulin Class Switching / immunology
Lymphocyte Activation*
T-Lymphocytes, Helper-Inducer / immunology*
T-Lymphocytes, Helper-Inducer / pathology

Substances

Autoantibodies
B-Cell Activating Factor
TNFSF13B protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding