Recurrent genetic defects on chromosome 7q in myeloid neoplasms

N Hosono; H Makishima; A Jerez; K Yoshida; B Przychodzen; S McMahon; Y Shiraishi; K Chiba; H Tanaka; S Miyano; M Sanada; I Gómez-Seguí; A K Verma; M A McDevitt; M A Sekeres; S Ogawa; J P Maciejewski

doi:10.1038/leu.2014.25

Recurrent genetic defects on chromosome 7q in myeloid neoplasms

Leukemia. 2014 Jun;28(6):1348-51. doi: 10.1038/leu.2014.25. Epub 2014 Jan 16.

Authors

N Hosono¹, H Makishima², A Jerez², K Yoshida³, B Przychodzen², S McMahon⁴, Y Shiraishi⁵, K Chiba⁵, H Tanaka⁶, S Miyano⁷, M Sanada³, I Gómez-Seguí², A K Verma⁸, M A McDevitt⁹, M A Sekeres¹⁰, S Ogawa³, J P Maciejewski¹¹

Affiliations

¹ 1] Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA [2] First Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
² Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
³ 1] Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan [2] Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto Japan.
⁴ Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
⁵ Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁶ Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁷ 1] Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan [2] Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁸ Albert Einstein College of Medicine, Bronx, NY, USA.
⁹ Divisions of Hematology and Hematological Malignancy, Departments of Internal Medicine and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹⁰ 1] Leukemia Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA [2] Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
¹¹ 1] Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA [2] Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 7 / genetics*
Enhancer of Zeste Homolog 2 Protein
Homeodomain Proteins / genetics*
Humans
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / mortality
Loss of Heterozygosity
Myelodysplastic Syndromes / genetics*
Myelodysplastic Syndromes / mortality
Myeloproliferative Disorders / genetics*
Myeloproliferative Disorders / mortality
Nuclear Proteins / genetics*
Polycomb Repressive Complex 2 / genetics*
Polymorphism, Single Nucleotide / genetics*
Prognosis
RNA-Binding Proteins / genetics*
Repressor Proteins / genetics*
Survival Rate
Transcription Factors

Substances

CUX1 protein, human
Homeodomain Proteins
LUC7L protein, human
Nuclear Proteins
RNA-Binding Proteins
Repressor Proteins
Transcription Factors
EZH2 protein, human
Enhancer of Zeste Homolog 2 Protein
Polycomb Repressive Complex 2

Publication types

MeSH terms

Substances

Grants and funding