Improved synthesis and structural reassignment of MC1568: a class IIa selective HDAC inhibitor

J Med Chem. 2014 Feb 13;57(3):1132-5. doi: 10.1021/jm401945k. Epub 2014 Jan 30.

Authors

Cassandra L Fleming¹, Trent D Ashton, Vidhi Gaur, Sean L McGee, Frederick M Pfeffer

Affiliation

¹ Research Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University , Waurn Ponds, Victoria, 3216, Australia.

PMID: 24450497
DOI: 10.1021/jm401945k

Abstract

An improved synthesis and structural reassignment of the class IIa selective histone deacetylase (HDAC) inhibitor MC1568 are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Histone Deacetylase Inhibitors / chemical synthesis*
Histone Deacetylase Inhibitors / chemistry
Hydroxamic Acids / chemical synthesis*
Hydroxamic Acids / chemistry
Molecular Structure
Pyrroles / chemical synthesis*
Pyrroles / chemistry

Substances

Histone Deacetylase Inhibitors
Hydroxamic Acids
MC1568
Pyrroles