Abstract
Six new tetraprenylated alkaloids, designated as malonganenones L-Q (1-6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1-6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1-6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC₅₀ values of 8.5 and 20.3 µM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors
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Alkaloids / administration & dosage
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Anthozoa / chemistry*
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China
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Cyclic Nucleotide Phosphodiesterases, Type 4 / drug effects
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Cyclic Nucleotide Phosphodiesterases, Type 5 / drug effects
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Inhibitory Concentration 50
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Oceans and Seas
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Phosphodiesterase Inhibitors / administration & dosage
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Phosphodiesterase Inhibitors / isolation & purification
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Phosphodiesterase Inhibitors / pharmacology*
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Spectrum Analysis
Substances
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Alkaloids
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Phosphodiesterase Inhibitors
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3',5'-Cyclic-AMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 4
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Cyclic Nucleotide Phosphodiesterases, Type 5