Molecular characterization of hepatitis A outbreak in the province of Rome, Lazio region, Italy, January-July 2013

Microbes Infect. 2014 Apr;16(4):362-6. doi: 10.1016/j.micinf.2014.01.003. Epub 2014 Jan 28.

Abstract

Reduced circulation of hepatitis A virus lead to an increase of susceptible individuals, and outbreaks occurred recently. In Northern Italy an outbreak is ongoing, attributed to a monophyletic genotype IA strain, with mixed frozen berries as probable source. From 01/01/2013 to 07/15/2013, 30 cases were diagnosed at National Institute for Infectious Diseases, Rome, Italy, representing about twice the number of cases in whole 2012. Phylogenetic analysis indicated that most, although not all, infections were attributable to the same monophyletic genotype IA strain identified in the contemporary Northern Italy outbreak. This strain is also very similar to previous isolates from Venezuela.

Keywords: Food-borne infections; Hepatitis A; Molecular characterization; Outbreak; Vaccine-preventable diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cluster Analysis
  • Disease Outbreaks*
  • Female
  • Genotype
  • Hepatitis A / epidemiology*
  • Hepatitis A / virology*
  • Hepatitis A virus / classification*
  • Hepatitis A virus / genetics*
  • Hepatitis A virus / isolation & purification
  • Humans
  • Italy / epidemiology
  • Male
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / genetics
  • Sequence Analysis, DNA
  • Sequence Homology

Substances

  • RNA, Viral

Associated data

  • GENBANK/KF475774
  • GENBANK/KF475775
  • GENBANK/KF475776
  • GENBANK/KF475777
  • GENBANK/KF475778
  • GENBANK/KF475779
  • GENBANK/KF475780