Abstract
For gene expression in non-cancerous complex diseases, we systemically evaluated the sensitivities of biological discoveries to violation of the common normalization assumption. Our results indicated that gene expression may be widely up-regulated in digestive system and musculoskeletal diseases. However, global signal intensities showed little difference in other four disease types.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Databases, Protein
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Female
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Female Urogenital Diseases / genetics
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Gastrointestinal Diseases / genetics*
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Gastrointestinal Diseases / metabolism
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Gene Expression
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Gene Expression Profiling
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Gene Expression Regulation / physiology*
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Humans
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Musculoskeletal Diseases / genetics*
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Musculoskeletal Diseases / metabolism
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Oligonucleotide Array Sequence Analysis / methods
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Pregnancy
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Pregnancy Complications / genetics
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Respiratory Tract Diseases / genetics
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Skin Diseases / genetics
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Transcriptome