To aim at the characteristics of epidemic situation that the imported falciparum malaria cases increased year by year in Yangzhou City, an imported falciparum malaria control system was established. This control system was based on enhancing the management of returned labor service export persons from falciparum malaria endemic areas, the active medical remind service, the diagnostic capability and health education, and the cooperation of medical personnel and patients, and also avoiding diagnosis delay and misdiagnosis and promoting the treatment in time so as to decrease the serious patients and prevent them from death. After the application of the control system, there were 164 imported falciparum malaria cases from the returned persons of labor service export. The time from the attack of the disease to the diagnosis confirmed decreased from 6.8 days before the application of the system to 2.7 days after the application, and the rate of serious patients was 1.8% and there were no death cases.