This report showed the endemic status of schistosomiasis in P. R. China at national level in 2012. By the end of 2012, the total number of schistosomiasis japonica cases were estimated to be 240597, with a decrease of 16.12% compared with that in 2011. Meanwhile, thirteen acute cases were reported. Compared with 2011, 10.34% more advanced schistosomiasis patients were treated (22988) in 2012. Nationally, around 368741.67 hm2 were found to be infested with Oncomelania hupensis snails by the end of 2012, among which 46.71 hm2 were newly reported. Moreover, 1 189829 cattle were estimated to be raised in epidemic regions with 0.52% of them being infected with Schistosoma japonicum, which experienced a reduction of 23.53% compared with that in 2011.