Metabolic syndrome and chronic kidney disease in a Southern Chinese population

Nephrology (Carlton). 2014 Jun;19(6):325-31. doi: 10.1111/nep.12219.

Abstract

Aim: To explore the relationship between metabolic syndrome (MS) and risk for chronic kidney disease (CKD) in a Southern Chinese population.

Methods: A cross-sectional study was conducted in 1724 community-based Southern Chinese participants from June to October 2012. The prevalence of MS (as defined by the International Diabetes Federation) and CKD (defined as an estimated glomerular filtration rate of <60 mL/min per 1.73 m(2) and/or albuminuria) was determined. The association between MS and CKD was then analyzed using STATA software.

Results: Metabolic syndrome was significantly associated with CKD (P < 0.001) in the unadjusted analyses as well as after adjustment for potential confounders. The unadjusted odds ratio and adjusted odds ratio for MS were 3.53 (95% confidence interval (CI) 2.62 to 4.75, P < 0.001) and 2.52 (95% CI 1.84 to 3.54, P < 0.001). When further adjusted for diabetes and hypertension, the association of MS and CKD was significant (odds ratio (OR) 1.63, 95% CI 1.15 to 2.32, P = 0.006). After adjustment for potential confounders, three components and four/five components were associated with CKD. The OR for three components and four/five components were 2.90 (95% CI 1.70 to 4.96, P < 0.001) and 3.64(95% CI 1.95 to 6.80, P < 0.001), when compared with those without components. High blood pressure, high serum triglyceride level, elevated fasting glucose level and central obesity were associated with CKD (P < 0.05). The odds ratios for elevated blood pressure, elevated serum triglyceride levels, elevated fasting glucose and central obesity were 1.80 (95% CI 1.25 to 2.62, P = 0.002), 1.56 (95% CI 1.14 to 2.14, P = 0.006), 2.54 (95% CI 1.82 to 3.57, P < 0.001), and 1.50 (95% CI 1.10 to 2.07, P = 0.01), respectively.

Conclusion: These findings suggest that MS is associated with CKD in Southern Chinese population, which may provide important information for the overall control of these diseases.

Keywords: Southern Chinese population; chronic kidney disease; metabolic syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Asian People / statistics & numerical data*
  • China / epidemiology
  • Confounding Factors, Epidemiologic
  • Cross-Sectional Studies
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Metabolic Syndrome / ethnology*
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Renal Insufficiency, Chronic / ethnology*
  • Risk Factors
  • Urban Population / statistics & numerical data
  • Young Adult