Molecular imaging for the characterization of breast tumors

Expert Rev Anticancer Ther. 2014 Jun;14(6):711-22. doi: 10.1586/14737140.2014.885383. Epub 2014 Feb 19.

Abstract

Recently, molecular imaging, using various techniques, has been assessed for breast imaging. Molecular imaging aims to quantify and visualize biological, physiological, and pathological processes at the cellular and molecular levels to further elucidate the development and progression of breast cancer and the response to treatment. Molecular imaging enables the depiction of tumor morphology, as well as the assessment of functional and metabolic processes involved in cancer development at different levels. To date, molecular imaging techniques comprise both nuclear medicine and radiological techniques. This review aims to summarize the current and emerging functional and metabolic techniques for the molecular imaging of breast tumors.

Keywords: MR spectroscopy; MRI; breast; breast tumors; molecular imaging; nuclear imaging; radiotracers.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Breast Neoplasms / blood supply
  • Breast Neoplasms / chemistry*
  • Breast Neoplasms / pathology
  • Carcinoma / blood supply
  • Carcinoma / chemistry*
  • Carcinoma / pathology
  • Estradiol / analogs & derivatives
  • Female
  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Humans
  • Magnetic Resonance Imaging / methods
  • Mammography / methods
  • Molecular Imaging / methods*
  • Multimodal Imaging
  • Positron-Emission Tomography
  • Proton Magnetic Resonance Spectroscopy
  • Radiopharmaceuticals
  • Sensitivity and Specificity
  • Technetium Tc 99m Sestamibi

Substances

  • 18-fluoro-17-estradiol
  • Biomarkers, Tumor
  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Estradiol
  • Technetium Tc 99m Sestamibi