Abstract
An exoselective copper-catalyzed arylation- and vinylation-carbocyclization of electron-deficient alkenes was developed to provide rapid and efficient access to a variety of functionalized 3,3-disubstituted oxindoles. With this method, a highly efficient and concise formal synthesis of (±)-physostigmine and (±)-physovenine has been completed.
MeSH terms
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Alkenes / chemistry*
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Catalysis
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Cations
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Copper / chemistry*
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Cyclization
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Electrons
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Indoles / chemistry
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Molecular Structure
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Oxindoles
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Physostigmine / analogs & derivatives*
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Physostigmine / chemical synthesis*
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Physostigmine / chemistry
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Stereoisomerism
Substances
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Alkenes
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Cations
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Indoles
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Oxindoles
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2-oxindole
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physovenine
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Copper
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Physostigmine
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cuprous chloride