"Orange alert": a fluorescent detector for bisphenol A in water environments

Anal Chim Acta. 2014 Mar 7:815:51-6. doi: 10.1016/j.aca.2014.01.038. Epub 2014 Jan 24.

Abstract

Due to the prevalent use of polycarbonate plastics and epoxy resins in packaging materials and paints for ships, there has been a widespread global contamination of environmental water sources with bisphenol A (BPA). BPA, an endocrine disruptor, has been found to cause tremendous health problems. Therefore, there is an urgent need for detecting BPA in a convenient and sensitive manner to ensure water safety. Herein, we develop a fluorescent turn-on BPA probe, named Bisphenol Orange (BPO), which could conveniently detect BPA in a wide variety of real water samples including sea water, drain water and drinking water. BPO shows superior selectivity toward BPA and up to 70-fold increase in fluorescence emission at 580 nm when mixed with BPA in water. Mechanistic studies suggest a plausible water-dependent formation of hydrophobic BPA clusters which favorably trap and restrict the rotation of BPO and recover its inherent fluorescence.

Keywords: Bisphenol A; Boron dipyrromethene; Fluorescent sensor; Water environments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzhydryl Compounds / analysis*
  • Drinking Water / chemistry
  • Endocrine Disruptors / analysis
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Phenols / analysis*
  • Seawater / chemistry
  • Spectrometry, Fluorescence*
  • Triazoles / chemical synthesis
  • Triazoles / chemistry
  • Water Pollutants, Chemical / analysis*

Substances

  • Benzhydryl Compounds
  • Drinking Water
  • Endocrine Disruptors
  • Fluorescent Dyes
  • Phenols
  • Triazoles
  • Water Pollutants, Chemical
  • bisphenol A