Infant 7-valent pneumococcal conjugate vaccine immunization alters young adulthood CD4(+)T cell subsets in allergic airway disease mouse model

Vaccine. 2014 Apr 11;32(18):2079-85. doi: 10.1016/j.vaccine.2014.02.013. Epub 2014 Feb 21.

Abstract

7-Valent pneumococcal conjugate vaccine (PCV7) immunization in adulthood can inhibit allergic asthma in mouse model. The aim of this study is to investigate the effects of infant PCV7 immunization on young adulthood CD4(+)T cell subsets in a murine allergic airway disease (AAD) model. Our study indicated that infant PCV7 immunization can inhibit young adulthood airway inflammation and airway hyperresponsiveness (AHR) by inducing the production of Foxp3(+)Treg, Th1 cells and their cytokines IL-10 and IFN-γ, inhibiting the production of Th2, Th17 cells and their cytokines IL-13 and IL-17A in BALB/c mice model. These results suggested that infant PCV7 immunization may serve as an effective measure to prevent young adulthood mice AAD.

Keywords: Allergic airway disease; Foxp3(+)Treg cell; Infant PCV7 immunization; Th17; Th2; Young adulthood.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Asthma / prevention & control*
  • Eosinophils / immunology
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Inflammation / prevention & control*
  • Interferon-gamma / immunology
  • Interleukin-10 / immunology
  • Lung / pathology
  • Mice
  • Mice, Inbred BALB C
  • Neutrophils / immunology
  • Pneumococcal Vaccines / immunology*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes, Regulatory / immunology
  • Th1 Cells / immunology
  • Th17 Cells / immunology
  • Th2 Cells / immunology

Substances

  • Heptavalent Pneumococcal Conjugate Vaccine
  • Pneumococcal Vaccines
  • Interleukin-10
  • Interferon-gamma