Autonomous device for application in late-phase hemorrhagic shock prevention

Vlad Oncescu; Seoho Lee; Abdurrahman Gumus; Kolbeinn Karlsson; David Erickson

doi:10.1371/journal.pone.0089903

Autonomous device for application in late-phase hemorrhagic shock prevention

PLoS One. 2014 Feb 24;9(2):e89903. doi: 10.1371/journal.pone.0089903. eCollection 2014.

Authors

Vlad Oncescu¹, Seoho Lee¹, Abdurrahman Gumus², Kolbeinn Karlsson², David Erickson¹

Affiliations

¹ Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America.
² Electrical and Computer Engineering, Cornell University, Ithaca, New York, United States of America.

Abstract

Hemorrhagic shock (HS) is the leading cause of death for people with traumatic injuries. The onset of HS is correlated with marked changes in the plasma vasopressin levels and some studies indicate that administrating vasopressin in the bloodstream can help stabilize the situation. This situation calls naturally for the use of implantable devices for both the monitoring and treatment of HS. In this work, we present a self-powered hemorrhagic-shock autonomous integrated device (hemoAID) that continuously monitors vasopressin levels and releases vasopressin automatically when levels drop below a certain threshold. We demonstrate that the device can operate at physiological concentrations of vasopressin, in sheep serum, thus paving the way towards the development of an autonomous implantable device for HS prevention.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Biosensing Techniques / instrumentation*
Infusion Pumps, Implantable*
Monitoring, Physiologic / instrumentation*
Nanowires
Sheep
Shock, Hemorrhagic / prevention & control*
Vasopressins / administration & dosage*
Vasopressins / blood
Vasopressins / therapeutic use

Substances

Vasopressins

Grants and funding

The authors wish to acknowledge the support of the Office of Naval Research (ONR) under award number N000141010115 “Autonomous Microfluidic Devices for Battlefield Health Assessment and Treatment”. In addition, V.O. wishes to acknowledge the support of the Canadian institution NSERC through a fellowship. Some elements of the integration were also carried out with the support of NSF grant #1014891. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.