Estrogen receptor and receptor tyrosine kinase signaling: use of combinatorial hormone and epidermal growth factor receptor/human epidermal growth factor receptor 2-targeted therapies for breast cancer

J Clin Oncol. 2014 Apr 1;32(10):1084-6. doi: 10.1200/JCO.2013.53.5070. Epub 2014 Mar 3.
No abstract available

MeSH terms

  • Antineoplastic Agents, Hormonal / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Class I Phosphatidylinositol 3-Kinases
  • ErbB Receptors / antagonists & inhibitors*
  • Female
  • Humans
  • Molecular Targeted Therapy
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism
  • Protein-Tyrosine Kinases / metabolism*
  • Receptor, ErbB-2 / antagonists & inhibitors*
  • Receptors, Estrogen / metabolism*
  • Signal Transduction

Substances

  • Antineoplastic Agents, Hormonal
  • Receptors, Estrogen
  • Phosphatidylinositol 3-Kinases
  • Class I Phosphatidylinositol 3-Kinases
  • PIK3CA protein, human
  • ERBB2 protein, human
  • ErbB Receptors
  • Protein-Tyrosine Kinases
  • Receptor, ErbB-2