Two elderly cases of familial mediterranean fever with rheumatoid arthritis

Int J Rheum Dis. 2018 Oct;21(10):1873-1877. doi: 10.1111/1756-185X.12354. Epub 2014 Mar 25.

Abstract

Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder that usually develops before 20 years of age and is characterized by periodic fever with serositis and arthritis. Both FMF and rheumatoid arthritis (RA) involve arthritis; however, their coexistence is rare. We describe two RA patients with an MEFV mutation in exon 2, who were diagnosed with FMF at an age of over 50 years. We also discuss the possibility that MEFV mutations could modulate RA disease activity.

Keywords: MEFV gene; familial Mediterranean fever; rheumatoid arthritis.

Publication types

  • Case Reports

MeSH terms

  • Age of Onset
  • Aged
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Rheumatoid / diagnosis
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / immunology*
  • Exons
  • Familial Mediterranean Fever / diagnosis
  • Familial Mediterranean Fever / drug therapy
  • Familial Mediterranean Fever / genetics*
  • Familial Mediterranean Fever / immunology
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Middle Aged
  • Mutation*
  • Phenotype
  • Pyrin / genetics*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Antirheumatic Agents
  • Immunosuppressive Agents
  • MEFV protein, human
  • Pyrin