AduoLa Fuzhenglin down-regulates microwave-induced expression of β1-adrenergic receptor and muscarinic type 2 acetylcholine receptor in myocardial cells of rats

Biomed Environ Sci. 2014 Mar;27(3):204-7. doi: 10.3967/bes2014.041.

Abstract

This paper is aimed to study the effect of ADL on expression of β1-AR and M2-AchR in myocardial cells of rats exposed to microwave radiation. Immunohistochemistry, Western blot and image analysis were used to detect the expression of β1-AR and M2-AchR in myocardial cells at 7 and 14 d after microwave exposure. The results show that the expression level was higher in microwave exposure group and 0.75 g/(kg•d) ADL group than in sham operation group and significantly lower in 1.5 and 3.0 g/(kg•d) ADL groups than in microwave group. So we have a conclusion that the expression of β1-AR and M2-AchR is down-regulated in myocardial cells of rats exposed to microwave radiation. ADL can protect rats against microwave-induced heart tissue injury.

MeSH terms

  • Animals
  • Down-Regulation / drug effects
  • Drugs, Chinese Herbal / pharmacology*
  • Heart / drug effects*
  • Male
  • Microwaves / adverse effects*
  • Myocardium / cytology
  • Myocardium / metabolism*
  • Protective Agents / pharmacology
  • Rats, Wistar
  • Receptor, Muscarinic M2 / metabolism*
  • Receptors, Adrenergic, beta-1 / metabolism*

Substances

  • Drugs, Chinese Herbal
  • Protective Agents
  • Receptor, Muscarinic M2
  • Receptors, Adrenergic, beta-1