A solvent- and metal-free synthesis of 3-chacogenyl-indoles employing DMSO/I2 as an eco-friendly catalytic oxidation system

J Org Chem. 2014 May 2;79(9):4125-30. doi: 10.1021/jo5000779. Epub 2014 Apr 18.

Abstract

Herein, we describe a solvent- and metal-free method for the synthesis of 3-chalcogenyl-indoles from indoles and diorganyl dichalcogenides using an equivalent amount of DMSO as an oxidant, under catalysis by molecular iodine. This mild and eco-friendly approach allowed the preparation of a wide range of 3-selenyl- and 3-sulfenyl-indoles in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Dimethyl Sulfoxide / chemistry*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Iodine / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Solvents / chemistry

Substances

  • Indoles
  • Solvents
  • Iodine
  • Dimethyl Sulfoxide