Results of the 4th scientific workshop of the ECCO (Group II): markers of intestinal fibrosis in inflammatory bowel disease

Florian Rieder; Jessica R de Bruyn; Bao Tung Pham; Konstantinos Katsanos; Vito Annese; Peter D R Higgins; Fernando Magro; Iris Dotan

doi:10.1016/j.crohns.2014.03.009

Results of the 4th scientific workshop of the ECCO (Group II): markers of intestinal fibrosis in inflammatory bowel disease

J Crohns Colitis. 2014 Oct;8(10):1166-78. doi: 10.1016/j.crohns.2014.03.009. Epub 2014 Apr 13.

Authors

Florian Rieder¹, Jessica R de Bruyn², Bao Tung Pham³, Konstantinos Katsanos⁴, Vito Annese⁵, Peter D R Higgins⁶, Fernando Magro⁷, Iris Dotan⁸

Affiliations

¹ Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA; Department of Gastroenterology & Hepatology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. Electronic address: riederf@ccf.org.
² Academic Medical Center Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands. Electronic address: j.r.debruyn@amc.uva.nl.
³ Division of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, University of Groningen, The Netherlands. Electronic address: b.t.pham@rug.nl.
⁴ Department of Gastroenterology, University Hospital of Ioannina, Medical School of Ioannina, Greece. Electronic address: khkostas@hotmail.com.
⁵ Division of Gastroenterology, University Hospital Careggi, Florence, Italy. Electronic address: annesev@aou-careggi.toscana.it.
⁶ Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. Electronic address: phiggins@med.umich.edu.
⁷ Department of Pharmacology & Therapeutics, Institute for Molecular and Cell Biology, Faculty of Medicine University of Porto, Porto, Portugal; Department of Gastroenterology, Hospital de Sao Joao, Porto, Portugal. Electronic address: fm@med.up.pt.
⁸ IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: irisd@tasmc.health.gov.il.

PMID: 24726695
DOI: 10.1016/j.crohns.2014.03.009

Abstract

The fourth scientific workshop of the European Crohn's and Colitis Organization (ECCO) focused on intestinal fibrosis in inflammatory bowel disease (IBD). The objective was to better understand basic mechanisms and markers of intestinal fibrosis as well as to suggest new therapeutic targets to prevent or treat fibrosis. The results of this workshop are presented in three separate manuscripts. This section describes markers of fibrosis in IBD, identifies unanswered questions in the field and provides a framework for future studies addressing the unmet needs in the field of intestinal fibrosis.

Keywords: Biomarkers; Crohn's disease;; Fibrosis;; Inflammatory bowel diseases;; Ulcerative colitis;.

Publication types

Review

MeSH terms

Biomarkers / metabolism
Bronchoalveolar Lavage Fluid / chemistry
Endoscopy, Gastrointestinal
Fibrosis
Humans
Inflammatory Bowel Diseases / diagnostic imaging
Inflammatory Bowel Diseases / genetics
Inflammatory Bowel Diseases / metabolism*
Inflammatory Bowel Diseases / pathology*
Intestines / pathology*
Kidney / pathology*
Liver Cirrhosis / blood
Liver Cirrhosis / diagnosis*
Proteome / metabolism
Pulmonary Fibrosis / metabolism*
Radiography
Skin / pathology*

Substances

Biomarkers
Proteome