Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks

Xiao Ling Li; Matthew F Jones; Murugan Subramanian; Ashish Lal

doi:10.1016/j.febslet.2014.03.054

Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks

FEBS Lett. 2014 Aug 19;588(16):2610-5. doi: 10.1016/j.febslet.2014.03.054. Epub 2014 Apr 12.

Authors

Xiao Ling Li¹, Matthew F Jones¹, Murugan Subramanian¹, Ashish Lal²

Affiliations

¹ Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
² Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: ashish.lal@nih.gov.

Abstract

MicroRNAs are potent regulators of gene expression and modulate multiple cellular processes including proliferation, differentiation and apoptosis. A number of microRNAs have been shown to be regulated by p53, the most frequently mutated gene in human cancer. It is has been demonstrated that some mutant p53 proteins not only lose tumor suppressor activity, but also acquire novel oncogenic functions that are independent of wild-type p53. In this review, we highlight recent evidences suggesting that some mutant p53 proteins regulate the expression of specific microRNAs to gain oncogenic functions and identify a gene network regulated by the microRNAs downstream of mutant p53.

Keywords: Cancer; Gain-of-function; Invasion; Let-7; Metastasis; Mutant p53; miR-128-2; miR-130b; miR-155; miR-205; miR-223; miR-27a; miRNA; microRNA.

Publication types

Review

MeSH terms

Animals
Gene Regulatory Networks*
Humans
MicroRNAs / genetics*
Mutation*
Neoplasms / genetics*
Neoplasms / metabolism
Tumor Suppressor Protein p53 / genetics*
Tumor Suppressor Protein p53 / metabolism*

Substances

MicroRNAs
Tumor Suppressor Protein p53

Grants and funding

ZIA BC011399-01/Intramural NIH HHS/United States