Familial haematuria: when to consider genetic testing

Arch Dis Child. 2014 Sep;99(9):857-61. doi: 10.1136/archdischild-2013-304827. Epub 2014 Apr 12.

Abstract

Haematuria is a common finding in children. It is important to identify the underlying cause whenever possible so that appropriate follow-up is organised, particularly if the child is at risk of developing renal impairment or renal failure in later life. Until recently nephrologists relied on renal biopsy with examination under the electron microscope to make a diagnosis, but genetic testing can often provide an answer, together with additional information about the pattern of inheritance, which is also useful for other family members.

Keywords: Deafness; Genetics; Molecular Biology; Nephrology; Ophthalmology.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Genetic Testing / methods*
  • Hematuria / diagnosis*
  • Hematuria / etiology
  • Hematuria / genetics
  • Humans