Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation: long-term incidence and outcome

Biol Blood Marrow Transplant. 2014 Aug;20(8):1238-41. doi: 10.1016/j.bbmt.2014.04.004. Epub 2014 Apr 13.

Abstract

Viral respiratory infections (VRIs) are frequent after hematopoietic stem cell transplantation and constitute a potential cause of mortality. We analyzed the incidence, risk factors, and prognosis of VRIs in a cohort of transplanted patients. More frequent viruses were human coronavirus and human rhinovirus followed by flu-like viruses and adenovirus. Risk factors for death were lymphocytopenia and high steroid dosage.

Keywords: Allogeneic hematopoietic stem cell transplantation; Respiratory viral infections.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hematopoietic Stem Cell Transplantation / mortality
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Multiplex Polymerase Chain Reaction / methods*
  • Respiratory Tract Infections / diagnosis*
  • Respiratory Tract Infections / etiology
  • Respiratory Tract Infections / virology
  • Transplantation Conditioning / adverse effects*
  • Transplantation Conditioning / mortality
  • Transplantation, Homologous / adverse effects*
  • Transplantation, Homologous / mortality
  • Treatment Outcome
  • Young Adult