Homonymous hemianopia due to Erdheim-Chester disease

J Neuroophthalmol. 2014 Sep;34(3):237-42. doi: 10.1097/WNO.0000000000000111.

Abstract

Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis typically affecting multiple organ systems. We report 2 patients who presented with homonymous hemianopia and were ultimately diagnosed with biopsy-confirmed ECD. We review the spectrum of ECD and its treatment as well as histopathological and immunohistochemical differentiation from other histiocytic disorders.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, CD / metabolism
  • Antigens, Differentiation, Myelomonocytic / metabolism
  • Brain / metabolism
  • Brain / pathology
  • Erdheim-Chester Disease / complications*
  • Extracellular Matrix Proteins / metabolism
  • Female
  • Hemianopsia / diagnosis
  • Hemianopsia / etiology*
  • Humans
  • Hyaluronan Receptors / metabolism
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Visual Fields / physiology

Substances

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD68 antigen, human
  • Extracellular Matrix Proteins
  • Hyaluronan Receptors
  • hyaluronan-mediated motility receptor