Prostaglandin E2: the villain in the host response to influenza virus

Florian Full; Michaela U Gack

doi:10.1016/j.immuni.2014.03.008

Prostaglandin E2: the villain in the host response to influenza virus

Immunity. 2014 Apr 17;40(4):453-4. doi: 10.1016/j.immuni.2014.03.008.

Authors

Florian Full¹, Michaela U Gack²

Affiliations

¹ Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
² Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: michaela_gack@hms.harvard.edu.

PMID: 24745327
DOI: 10.1016/j.immuni.2014.03.008

Abstract

Prostaglandins are lipid mediators that are involved in a plethora of biological processes. In this issue of Immunity, Coulombe et al. (2014) report that prostaglandin E2 suppresses innate and adaptive immune responses to influenza virus.

Publication types

Comment

MeSH terms

Animals
Dinoprostone / metabolism*
Influenza A virus / physiology*
Interferon Type I / metabolism*
Intramolecular Oxidoreductases / antagonists & inhibitors*
Macrophages / drug effects*
Orthomyxoviridae Infections / drug therapy*
Prostaglandin-E Synthases

Substances

Interferon Type I
Intramolecular Oxidoreductases
Prostaglandin-E Synthases
Dinoprostone