Evaluating the role of mitochondrial DNA variation to the genetic predisposition to radiation-induced toxicity

Radiother Oncol. 2014 May;111(2):199-205. doi: 10.1016/j.radonc.2014.03.012. Epub 2014 Apr 17.

Abstract

Background and purpose: Mitochondrial DNA common variants have been reported to be associated with the development of radiation-induced toxicity. Using a large cohort of patients, we aimed to validate these findings by investigating the potential role of common European mitochondrial DNA SNPs (mtSNPs) to the development of radio-toxicity.

Material and methods: Overall acute and late toxicity data were assessed in a cohort of 606 prostate cancer patients by means of Standardized Total Average Toxicity (STAT) score. We carried out association tests between radiation toxicity and a selection of 15 mtSNPs (and the haplogroups defined by them).

Results: Statistically significant association between mtSNPs and haplogroups with toxicity could not be validated in our Spanish cohort.

Conclusions: The present study suggests that the mtDNA common variants analyzed are not associated with clinically relevant increases in risk of overall radiation-induced toxicity in prostate cancer patients.

Keywords: 3D-CRT; Prostate cancer; SNP; mtDNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Mitochondrial / genetics*
  • Genetic Predisposition to Disease*
  • Genetic Variation*
  • Genotype
  • Humans
  • Male
  • Multivariate Analysis
  • Phylogeny
  • Polymorphism, Single Nucleotide
  • Prospective Studies
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / radiotherapy*
  • Radiation Injuries / genetics*
  • Radiotherapy, Conformal / adverse effects*
  • Spain
  • White People

Substances

  • DNA, Mitochondrial